The Predictive Factors for Recurrence of Spontaneous Bacterial Peritonitis

Document Type : Original article

Authors

1 Tropical Medicine dept., Mansoura Univ., Egypt.

2 Clinical Pathology dept., Mansoura Univ., Egypt

3 Internal Medicine dept., Mansoura Univ., Egypt.

4 Microbiology and Immu-nology dept., Mansoura Univ., Egypt

5 Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Biostatistics dept., South Egypt Cancer Institute, Assiut Univ., Egypt.

Abstract

Background and objectives: Spontaneous bacterial peritonitis
(SBP) is a common and critical complication of cirrhosis. The
aim of this work is to find the possible predictive factors for
recurrence of SBP in decompensated cirrhotic patients.
Patients and methods: This study included one hundred
and thirty-four cirrhotic ascitic patients who were diagnosed with
SBP. The diagnosis of SBP was based on ascitic polymorphonuclear
leukocytes (PMN) counts ≥250 cells/mm3. The studied
patients were classified into two groups; group 1 included sixtyninth
patients with recurrent SBP and group 2; included
sixty-five patients with non-recurrent SPB. Results: A
significant difference was found between both studied groups as
regards the presence of fever, HRS (hepatorenal syndrome,
the serum albumin and the ascitic fluid PMN in ascitic
cirrhotic patients (P= 0.010, p= 0.001, p=0.021, p= 0.045
respectively). Furthermore, a multivariate analysis revealed that
the presence of fever, hepatorenal syndrome, and increased
ascitic fluid PMN represent independent variables predict the
recurrence of SBP in cirrhotic ascetic patients (p= 0.001 for all).
Conclusion: Our study revealed that the presence of fever, HRS,
and increased PMN count in ascitic fluid were independent
predictors of recurrence of SBP in cirrhotic ascetic patients..

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