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Alaa, H., Mahmoud, A., Dalia, S., Somaia, S., Sheren, Y., Esmat, M. (2019). Value of Cytokeratin-18 as a non-invasive diagnostic biomarker of nonalcoholic steatohepatitis (NASH). Medical Journal of Viral Hepatitis, 3.2(2), 65-74. doi: 10.21608/mjvh.2019.55732
Habib Alaa; Awad Mahmoud; Shaheen Dalia; Shehab-Eldeen Somaia; Younes Sheren; Mohammed Esmat. "Value of Cytokeratin-18 as a non-invasive diagnostic biomarker of nonalcoholic steatohepatitis (NASH)". Medical Journal of Viral Hepatitis, 3.2, 2, 2019, 65-74. doi: 10.21608/mjvh.2019.55732
Alaa, H., Mahmoud, A., Dalia, S., Somaia, S., Sheren, Y., Esmat, M. (2019). 'Value of Cytokeratin-18 as a non-invasive diagnostic biomarker of nonalcoholic steatohepatitis (NASH)', Medical Journal of Viral Hepatitis, 3.2(2), pp. 65-74. doi: 10.21608/mjvh.2019.55732
Alaa, H., Mahmoud, A., Dalia, S., Somaia, S., Sheren, Y., Esmat, M. Value of Cytokeratin-18 as a non-invasive diagnostic biomarker of nonalcoholic steatohepatitis (NASH). Medical Journal of Viral Hepatitis, 2019; 3.2(2): 65-74. doi: 10.21608/mjvh.2019.55732

Value of Cytokeratin-18 as a non-invasive diagnostic biomarker of nonalcoholic steatohepatitis (NASH)

Article 5, Volume 3.2, Issue 2, April 2019, Page 65-74  XML PDF (516.2 K)
Document Type: Original article
DOI: 10.21608/mjvh.2019.55732
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Authors
Habib Alaa1; Awad Mahmoud1; Shaheen Dalia2; Shehab-Eldeen Somaia3; Younes Sheren4; Mohammed Esmat5
1Internal Medicine dept, Faculty of Medicine, Mansoura Univ., Egypt.
2Medical Biochemistry dept., Faculty of Medicine, Mansoura Univ., Egypt.
3Tropical Medicine dept., Faculty of Medicine, Menoufia Univ., Egypt.
4Pathology dept., Faculty of Medicine, Menoufia Univ., Egypt.; Histopathology dept., College of Medicine, Princess Nourah Bint Abdul Rahman Univ., KSA
5Radiology dept., National Institute of Cancer, Cairo University, Egypt
Abstract
Background and study aim: Liver biopsy couldn’t be utilized
for screening of nonalcoholic steatohepatitis (NASH), as it is
considered invasive, and has many complications. The study
aims to investigate the value of serum levels of CK -18
fragments as a diagnostic biomarker for NASH and NAFLD
and its correlation with severity of NASH as measured by
NAFLD activity score (NAS) of liver biopsies. Patients and
methods: A total number of 46 subjects with biopsy-proven
non-alcoholic steatohepatitis (NASH group) and 54 subjects
with borderline NASH, simple steatosis and normal liver
tissue (non-NASH group) as well as 30 age-matched healthy
volunteers were included in the study. Scoring of liver
biopsies using the NAFLD activity score (NAS) and measurement
of CK-18 in sera was done. Results: The serum level of
cytokeratin-18 was significantly higher in the NASH group
when compared to non-NASH group (P=0.0123) or controls
(P=0.00001). Using the ROC curve, the optimal value of cytokeratin-
18 was 487U/L, with sensitivity 69 % and specificity
84.5 % in detecting NASH. Serum CK-18 levels were significantly
correlated to the disease severity as measured by liver
biopsy (degree of steatosis, fibrosis, lobular inflammation,
and ballooning) in NASH patients. Conclusions: Serum CK-
18 could be used as a non-invasive diagnostic serum marker
for patients of NAFLD and NASH.
Keywords
Cytokeratin-18; NASH; NAFLD
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