Elkady, M., Omar, M., Saif Elnaser, M., Roshdy, N. (2024). Mortality risk and associated factors in cirrhosis patients with SARS-CoV-2 infection. Medical Journal of Viral Hepatitis, 8.1(1), 9-16. doi: 10.21608/mjvh.2024.350727
Mostafa Elkady; Maha Omar; Mounir Saif Elnaser; Noha Roshdy. "Mortality risk and associated factors in cirrhosis patients with SARS-CoV-2 infection". Medical Journal of Viral Hepatitis, 8.1, 1, 2024, 9-16. doi: 10.21608/mjvh.2024.350727
Elkady, M., Omar, M., Saif Elnaser, M., Roshdy, N. (2024). 'Mortality risk and associated factors in cirrhosis patients with SARS-CoV-2 infection', Medical Journal of Viral Hepatitis, 8.1(1), pp. 9-16. doi: 10.21608/mjvh.2024.350727
Elkady, M., Omar, M., Saif Elnaser, M., Roshdy, N. Mortality risk and associated factors in cirrhosis patients with SARS-CoV-2 infection. Medical Journal of Viral Hepatitis, 2024; 8.1(1): 9-16. doi: 10.21608/mjvh.2024.350727
Mortality risk and associated factors in cirrhosis patients with SARS-CoV-2 infection
1Hepatology, Gastroenterology and Infectious Diseases dept., Faculty of Medicine, Benha Univ., Egypt
2Fever, Hepatology and Gastroenterology Menof Hospital, Egypt.
3Fever, Hepatology and Gastroenterology Menof Hospital, Egypt. Hepatology, Gastroenterology and Infectious Diseases dept., Faculty of Medicine, Benha Univ., Egypt.
Abstract
Background: The SARS-CoV-2 virus causes the severe illness known as COVID-19. Globally, liver cirrhosis is a leading cause of death. This study seeks to evaluate the severity of COVID-19 and identify factors that predict mortality in patients with cirrhosis. Patients and methods: The study involved 156 COVID-19 patients, with 78 in the liver cirrhosis group (group 1) and 78 in the non-cirrhosis group (group 2). Each case underwent a clinical examination, general history taking, laboratory and radiological investig-ations. The severity of liver disease was assessed in cirrhosis patients using the Child-Pugh and MELD scores. Data were collected at presentation and upon ICU admission included mortality rate. Results: The mortality rate was significantly higher in cirrhotic group group (56.4%) compared to non- cirrhotic group (32.1%) (p=0.002). In cirrhotic group, the Child-Pugh and MELD scores were significantly higher in the dead cases compared to the survivors. Multivariate regression analysis identified older age, ICU duration, and presence of chronic kidney disease, cardiovascular disease, hepatoma, dyspnea, ascites, respiratory rate, WBCs, D-dimer level, CRP, serum albumin, and CT CORADS as independent risk factors for mortality in cirrhotic group. Conclusion: Patients with chronic liver diseases had a higher risk of poor outcomes when they got COVID-19 compared to those without liver diseases. Among patients with liver cirrhosis, those who died had significantly higher Child-Pugh and MELD scores than survivors.
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