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Mosaad, A., Elalfy, H., Amer, T., Arafa, M. (2022). Transient Elastography and its Correlation with Biochemical Scores in patients with Metabolic associated fatty liver disease. Medical Journal of Viral Hepatitis, 6.3(3), 22-28. doi: 10.21608/mjvh.2022.258088
Ahmed Mosaad; Hatem Elalfy; Talaal Amer; Mona Arafa. "Transient Elastography and its Correlation with Biochemical Scores in patients with Metabolic associated fatty liver disease". Medical Journal of Viral Hepatitis, 6.3, 3, 2022, 22-28. doi: 10.21608/mjvh.2022.258088
Mosaad, A., Elalfy, H., Amer, T., Arafa, M. (2022). 'Transient Elastography and its Correlation with Biochemical Scores in patients with Metabolic associated fatty liver disease', Medical Journal of Viral Hepatitis, 6.3(3), pp. 22-28. doi: 10.21608/mjvh.2022.258088
Mosaad, A., Elalfy, H., Amer, T., Arafa, M. Transient Elastography and its Correlation with Biochemical Scores in patients with Metabolic associated fatty liver disease. Medical Journal of Viral Hepatitis, 2022; 6.3(3): 22-28. doi: 10.21608/mjvh.2022.258088

Transient Elastography and its Correlation with Biochemical Scores in patients with Metabolic associated fatty liver disease

Article 4, Volume 6.3, Issue 3, August 2022, Page 22-28  XML PDF (264.51 K)
Document Type: Original article
DOI: 10.21608/mjvh.2022.258088
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Authors
Ahmed Mosaad* 1; Hatem Elalfy1; Talaal Amer2; Mona Arafa1
1Tropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2Department of Radiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
Background: Metabolic-associated fatty liver disease (MAFLD) is a recently terminology to refer to the diseases within the field of fatty liver disease. The aim of this study is to evaluate the value of transient elastography (TE) in MAFLD patients and its correlation with clinical and biochemical scores for assessment of liver fibrosis.
Methods:This study was carried out on 97 patients with MAFLD. All patients had undergone pelvi–abdominal ultra-sound as a screening tool, transient elastography to determine degree of steatosis/fibrosis, laboratory work up and calculation of FIB-4, APRI, NAFLD fibrosis score (NFS).
Results:Based on the results of transient elastography, the studied MAFLD patients were classified into two groups; group (1) included 62 patients without fibrosis (F0 ≤  6 KP) and group 2 included 35 patients with fibrosis (> 6 KP).  There was significant increasing as regarding FIB4, APRI, and NFS in MAFLD patients with fibrosis versus patients without fibrosis, while controlled attenuation parameter (CAP) does not show significant difference. In patients with fibrosis (group 2) there was statistically significant positive correlation of LSM with FIB4, NFS (P< 0.0001), APRI (P= 0.001), while a non-significant negative correlation of LSM with CAP was detected (P = 0.2), furthermore, there was statistically significant correlation of LSM with age,2 hours postprandial blood sugar, HbA1c, triglycerides, serum creatinine, uric acid and platelets.
Conclusion:In MAFLD patients, transient elastography is a simple, non-invasive and inexpensive method that correlates with other non-invasive assessment scores of liver fibrosis.
 
Keywords
Metabolic associated fatty liver disease; Transient Elastography
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