Anyovi, F., Soulier, A., Poiteau, L., Soliman, R., Karou, S., Simpore, J., Chevaliez, S., Shiha, G. (2021). Genetic Variability of NS5B Region of Hepatitis C Virus in Togo. Medical Journal of Viral Hepatitis, 5.3(3), 8-13. doi: 10.21608/mjvh.2021.193420
Folly Anyovi; Alexandre Soulier; Lila Poiteau; Reham Soliman; Simplice D. Karou; Jacques Simpore; Stephane Chevaliez; Gamal Shiha. "Genetic Variability of NS5B Region of Hepatitis C Virus in Togo". Medical Journal of Viral Hepatitis, 5.3, 3, 2021, 8-13. doi: 10.21608/mjvh.2021.193420
Anyovi, F., Soulier, A., Poiteau, L., Soliman, R., Karou, S., Simpore, J., Chevaliez, S., Shiha, G. (2021). 'Genetic Variability of NS5B Region of Hepatitis C Virus in Togo', Medical Journal of Viral Hepatitis, 5.3(3), pp. 8-13. doi: 10.21608/mjvh.2021.193420
Anyovi, F., Soulier, A., Poiteau, L., Soliman, R., Karou, S., Simpore, J., Chevaliez, S., Shiha, G. Genetic Variability of NS5B Region of Hepatitis C Virus in Togo. Medical Journal of Viral Hepatitis, 2021; 5.3(3): 8-13. doi: 10.21608/mjvh.2021.193420
Genetic Variability of NS5B Region of Hepatitis C Virus in Togo
1Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR-SVT, Joseph KI-ZERBO University, Ouagadougou, Burkina Faso.
2Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso.
3Centre National de Référence des Hépatites virales B, C et delta, Laboratoire de Virologie, hôpital Henri Mondor, Université Paris-Est, Créteil.
4INSERM U955, Créteil.
53Centre National de Référence des Hépatites virales B, C et delta, Laboratoire de Virologie, hôpital Henri Mondor, Université Paris-Est, Créteil.
6INSERM U955, Créteil
7Egyptian Liver Research Institute and Hospital (ELRIAH), Sherbin, El Mansoura, Egypt
8Tropical Medicine Department, Faculty of Medicine, Port Said University, Egypt
95Ecole Supérieure des Techniques Biologiques et Alimentaires (ESTBA), Université de Lomé.
10Internal Medicine dept., Mansoura Univ., Egypt
11Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt.
Abstract
Background: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The high prevalence and spread rates of the disease require serious actions to stop these rates. Determination of HCV genotypes and subgenotypes adds significant knowledge about the epidemiology of the disease, and provides and added value in the decision-making process of what strategy to follow and what therapy response to expert. The molecular epidemiology and genetic variability of HCV variant circulating in Togo still need further analysis. Materials and methods: The HCV molecular epidemiology in Togo was studies using direct sequencing and further phylogenetic analysis of a partial NS5B region of the HCV from 56 patients. HCV genotype and subtype were successfully determined in 41 out of 53. Results: The highest prevalent genotype was genotype 2, which was found in 30 patients (73,2%) followed by genotype 1 that was isolated from 7 patients (17,1%), genotype 4 was isolated from 3 patients (7,3%) and 1 patient (2,4%) was infected by genotype 6. Conclusion: The molecular epidemiology study revealed high prevalence of genotype 2 among Togolese patients followed by genotype 1.
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