Habeeb, M., Saad, R., Elhammady, D., Zaki, M., Abbas, N. (2021). Role of interferon gamma gene polymorphism in spontaneous viral clearance versus chronicity in hepatitis C infected Egyptian patients. Medical Journal of Viral Hepatitis, 6.1(1), 24-31. doi: 10.21608/mjvh.2021.211709
Maha R Habeeb; Rokia Anwar Saad; Dina Elhammady; Maysaa ElSayed Zaki; Neven Farouk Abbas. "Role of interferon gamma gene polymorphism in spontaneous viral clearance versus chronicity in hepatitis C infected Egyptian patients". Medical Journal of Viral Hepatitis, 6.1, 1, 2021, 24-31. doi: 10.21608/mjvh.2021.211709
Habeeb, M., Saad, R., Elhammady, D., Zaki, M., Abbas, N. (2021). 'Role of interferon gamma gene polymorphism in spontaneous viral clearance versus chronicity in hepatitis C infected Egyptian patients', Medical Journal of Viral Hepatitis, 6.1(1), pp. 24-31. doi: 10.21608/mjvh.2021.211709
Habeeb, M., Saad, R., Elhammady, D., Zaki, M., Abbas, N. Role of interferon gamma gene polymorphism in spontaneous viral clearance versus chronicity in hepatitis C infected Egyptian patients. Medical Journal of Viral Hepatitis, 2021; 6.1(1): 24-31. doi: 10.21608/mjvh.2021.211709
Role of interferon gamma gene polymorphism in spontaneous viral clearance versus chronicity in hepatitis C infected Egyptian patients
1Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
2Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
3Department of Tropical Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
4Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Abstract
Background: Polymorphisms in the cytokine gene involving IFN gamma (IFN-γ) have been implicated in many infections including HCV. The aim of this study is to evaluate the association between IFN-γ polymorphism in three regions, (+2109A/G, +874A/T, -183G/T) and either chronicity or spontaneous viral clearance (SCV) in HCV infected patients. Materials and Methods: The study included 200 HCV-infected patients divided into Group I of 100 patients with spontaneous virus clearance (SVC) and Group II of 100 patients with persistent chronic hepatitis C infection (PI) who did not receive any therapy. These patients were subjected to history taking, full clinical examination and laboratory investigations included analysis of IFN-γ gene polymorphisms. Results: At locus +2109 of the IFN-γ gene, patients with A/A genotype had a significantly higher rate of spontaneous hepatitis C clearance while the G/G genotype was more prone to persistent infection. No statistically significant difference was found between both groups regarding loci +874 and -183 of the IFN-γ gene, but column proportion comparison using Bonferroni method at locus +874 revealed a higher proportion for T/A genotype in SVC group. Both haplotypes AAT and TGT were more susceptible to chronic HCV infection, as were heterozygote T/A at locus +874 and G/G genotype at locus +2109s. A/G and A/A genotypes at locus +2109, TLC at cut off value ≤7.15, and AST at cut off value ≤27.5 were considered independent predictors for development of SVC. Conclusions: Polymorphisms in the IFN-γ gene may play role in sequelae following HCV infection, possibly determining whether the virus will be cleared spontaneously or not.
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